Ian Milton
As Technical Director of Bioconnexions Consulting Ltd, Dr Milton provides a strong scientific background. Dr Milton gained his PhD at the University of Newcastle upon Tyne and began his career in the development of monoclonal antibodies in a University spin-out company called Novocastra Laboratories Ltd over 20 years’ ago. This was the origin of his experience in biotechnology research and development. Over this period Dr Milton became involved in both general management and R&D management. Specifically he has gained detailed experience in the implementation and management of control systems for the design and manufacture of in vitro diagnostic products.

Dr Milton has extensive experience in guiding fast growing organizations through post-acquisition cultural change and the transition from private to public ownership. In 2002, Novocastra was acquired by an Australian company, Vision BioSystems Ltd. This resulted in considerable change and growth for the Novocastra facility now called Vision BioSystems Newcastle Ltd. Subsequently in 2007 Vision BioSystems Ltd was acquired by the Danaher Corporation and incorporated into Leica Microsystems to create the Biosystems Division Leica Biosystems Newcastle Ltd.

Each acquisition was with a back drop of great regulatory change in the EU, USA and China. This provided Dr Milton with experience in the implementation of changes required to transform the company to comply with ISO design and manufacturing standards and conformity to FDA and SFDA standards and subsequent release of IVD labeled products.

Ian Milton
Ian Milton
• 2011 Chief Scientific Officer, Leica Biosystems Newcastle Ltd.

• 2008 Managing Director, Leica Biosystems Newcastle Ltd.

• 2003 Research and Operations Director, Vision Biosystems Newcastle Ltd.

• 2001 Research Director, Novocastra Laboratories Ltd.

• 1994 Research and Development Manager, Novocastra Laboratories Ltd.

Ian Milton
Ian Milton
A monoclonal antibody for detection of folylpolyglutamate synthetase in paraffin embedded tissues. Quinn AE, Pinkney M, Piggott NH, Calvert H, Milton ID, Lunec J. Hybridoma (Larchmt). 2009 Dec;28(6):415-21. doi: 10.1089/hyb.2009.0040.

A novel monoclonal antibody for detection of folate receptor alpha in paraffin-embedded tissues. Smith AE, Pinkney M, Piggott NH, Calvert H, Milton ID, Lunec J. Hybridoma (Larchmt). 2007 Oct;26(5):281-8.

Wild-type estrogen receptor beta expression in normal and neoplastic paraffin-embedded tissues. Rees ML, Marshall I, McIntosh GG, Gray J, Mitchell K, Pinkney M, Piggott NH, Horne CH, Milton ID. Hybrid Hybridomics. 2004 Feb;23(1):11-8.

NCL-CD10-270: a new monoclonal antibody recognizing CD10 in paraffin-embedded tissue. McIntosh GG, Lodge AJ, Watson P, Hall AG, Wood K, Anderson JJ, Angus B, Horne CH, Milton ID. Am J Pathol. 1999 Jan;154(1):77-82.

The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study. Fray AE, Ince PG, Banner SJ, Milton ID, Usher PA, Cookson MR, Shaw PJ. Eur J Neurosci. 1998 Aug;10(8):2481-9.

Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study. Milton ID, Banner SJ, Ince PG, Piggott NH, Fray AE, Thatcher N, Horne CH, Shaw PJ. Brain Res Mol Brain Res. 1997 Dec 1;52(1):17-31.

New monoclonal antibodies to oestrogen and progesterone receptors effective for paraffin section immunohistochemistry. Bevitt DJ, Milton ID, Piggot N, Henry L, Carter MJ, Toms GL, Lennard TW, Westley B, Angus B, Horne CH. J Pathol. 1997 Oct;183(2):228-32.

Production and characterization of a new monoclonal antibody effective in recognizing the CD3 T-cell associated antigen in formalin-fixed embedded tissue. Steward M, Bishop R, Piggott NH, Milton ID, Angus B, Horne CH. Histopathology. 1997 Jan;30(1):16-22.

Feline calicivirus strain differentiation using monoclonal antibody analysis in an enzyme-linked immuno-flow-assay. McArdle F, Dawson S, Carter MJ, Milton ID, Turner PC, Meanger J, Bennett M, Gaskell RM. Vet Microbiol. 1996 Aug;51(3-4):197-206.

Prokaryotic expression and analysis of the antibody response to a Newcastle isolate of the core gene of hepatitis C. Milton ID, Watson JP, Guo K, Carter MJ, Bassendine MF, Toms GL. J Med Virol. 1995 Mar;45(3):253-8.

A gene probe to detect feline calicivirus from tissue samples. Meanger J, Dawson S, Milton ID, Carter MJ, Gaskell RM, Turner PC. Biochem Soc Trans. 1993 Nov;21(4):465S.

An inexpensive and simple method for DNA purifications on silica particles. Carter MJ, Milton ID. Nucleic Acids Res. 1993 Feb 25;21(4):1044.

Scheme of RNA transcription in calicivirus-infected cells. Meanger J, Carter MJ, Milton ID, Bennett M, Gaskell RM, Turner PC. Biochem Soc Trans. 1993 Feb;21(1):67S.

Cloning and sequencing of a plasmid-mediated erythromycin resistance determinant from Staphylococcus xylosus. Milton ID, Hewitt CL, Harwood CR. FEMS Microbiol Lett. 1992 Oct 1;76(1-2):141-7.

The complete nucleotide sequence of a feline calicivirus. Carter MJ, Milton ID, Meanger J, Bennett M, Gaskell RM, Turner PC. Virology. 1992 Sep;190(1):443-8.

Location of monoclonal antibody binding sites in the capsid protein of feline calicivirus. Milton ID, Turner J, Teelan A, Gaskell R, Turner PC, Carter MJ. J Gen Virol. 1992 Sep;73 (Pt 9):2435-9.

Genomic 3' terminal sequence comparison of three isolates of rabbit haemorrhagic disease virus. Milton ID, Vlasak R, Nowotny N, Rodak L, Carter MJ. FEMS Microbiol Lett. 1992 May 15;72(1):37-42.

Identification and sequence determination of the capsid protein gene of feline calicivirus. Carter MJ, Milton ID, Turner PC, Meanger J, Bennett M, Gaskell RM. Arch Virol. 1992;122(3-4):223-35.

Ian Milton